System Requirements

We support the following NVIDIA solutions:

Architecture Server / HPC Workstation

Tesla P40

Tesla P100

Quadro P5000

Tesla V100



Tesla T4

Quadro RTX 5000


Tesla A100

RTX A4000

RTX A5000

Ada Lovelace








  • Support for the Tesla M40 and M60 cards is deprecated.



  • We support only the NVIDIA 'recommended / certified / production branch' Linux drivers for these cards with minimum CUDA version 12.0.

  • Standard support does not cover consumer-level GPU cards such as GeForce GTX cards.

  • In the 2024-2 release, the "Discounted Cores" of an L4 was decreased from 7424 to 5120. This adjustment was made to align with the L4's status as a preferred card due to its widespread availability on-premises and through cloud providers. Additionally, the L4's low power consumption, speed, and sufficient memory make it suitable for running the majority of workflows in a configuration with one GPU per node.

  • If you already have another NVIDIA GPGPU and would like to know if we have experience with it, please contact our support at


To use Prime for homology modeling, you must install or have access to the PDB, the BLAST program and associated sequence databases, and the HMMER program and Pfam database. The required third-party programs, the BLAST database for web-based searching, and the Pfam database are provided in the download and on DVD, and are installed automatically when you install the software.

If you install the third party products and databases from the DVDs supplied by Schrödinger, you must run the INSTALL script for each DVD. Do not change DVDs while the INSTALL script is being executed: if you do, the script will fail.

Use of PSIPRED is also highly recommended for secondary structure predictions and for GPCR modeling. PSIPRED is not available on Windows. PSIPRED is not distributed as part of the Schrödinger software package—see Installing Prime Third-Party Software and Databases on Linux for information on obtaining and installing this program on Linux.

Information on the third-party software and databases can be found at the following locations:






The following topics provide installation and setup information.

Installing Local Copies of the Prime Third-Party Software and Databases

Setting Environment Variables for the Prime Third-Party Software and Databases